AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |
Back to Blog
Long term carbon monoxide poisoning symptoms11/12/2023 5 Messier and Myers 6 constructed a neuropsychological screening battery (CONSB) to improve the neurological assessment of carbon monoxide neurotoxicity. The symptoms may be subtle, nonspecific, and more difficult to detect in a bedside neurologic examination. Signs of carbon monoxide neurotoxicity may occur at low levels of exposure as well. Further elevations of HbCO levels in the blood are associated with lethargy, coma, seizures, and death. 4 Early symptoms of carbon monoxide neurotoxicity consist of headache and fatigue (HbCO levels, 0.1-0.2), while more advanced symptoms consist of dizziness and syncope (HbCO levels, 0.2-0.3). The neurologic manifestations that result from exposure to carbon monoxide are diverse. 2 Carboxyhemoglobin levels of 0.06 have been reported to precipitate cardiac arrhythmias. In patients with coronary heart disease, inhalation of slightly elevated concentrations of carbon monoxide in air produces mean blood carboxyhemoglobin (HbCO) levels of 0.02 to 0.04 and causes coronary ischemia. The effect of low-level exposure to carbon monoxide on the heart is well documented. 1 The severity of carbon monoxide toxicity ranges from subclinical or occult poisoning to severe morbidity and death. Neuropsychological testing appears to be sensitive in the detection of subtle neurologic dysfunctions resulting from carbon monoxide poisoning.ĬARBON MONOXIDE poisoning results primarily in cardiac and neurologic damage. Low-level exposure to carbon monoxide results in impairment of higher cognitive functions. These dysfunctions correspond with previous reports of carbon monoxide neurotoxic effects in patients with moderate carbon monoxide poisoning. No significant differences were found between the experimental and control groups in other tests.Ĭonclusions The lower scores on neuropsychological tests indicate dysfunctions in memory, new learning ability, attention and concentration, tracking skills, visuomotor skills, abstract thinking, and visuospatial planing and processing. The experimental group scored significantly lower than controls on the following tests: digit span forward ( P=.02), short-term ( P=.008) and long-term semantic memory ( P=.008), digit symbol ( P=.004), block design ( P=.009), recall of figural memory ( P=.02), and Trail-Making part A ( P=.04). Results Venous blood carboxyhemoglobin (HbCO) levels in participants of the study group ranged from 0.01 to 0.11 (mean ± SD, 0.04 ± 0.03) and correlated with air carbon monoxide concentrations ( r=0.39 P=.01). Main Outcome Measures A battery of neuropsychological tests was administered to each participant including digit span, the revised Wechsler Memory Scale for verbal and figural memory, Trail-Making Test parts A and B, digit symbol, block design, and the Rey Auditory Verbal Learning Test. Participants Forty-five student volunteers who were exposed to carbon monoxide from residential kerosene stoves for 1.5 to 2.5 hours (air carbon monoxide concentrations of 17-100 ppm mean ± SD, 61 ± 24 ppm) served as the experimental group and 47 nonexposed students served as the control group. Setting A dormitory at the Hebrew University campus in Jerusalem, Israel. Objective To investigate the effects of acute low-level exposure to carbon monoxide on higher cognitive functions in healthy humans.ĭesign An empirical study of the effects of low-level exposure to carbon monoxide on higher cognitive functions in young healthy volunteers and a matched nonexposed control group.
0 Comments
Read More
Leave a Reply. |